Cardiovascular Disease in Patients With Chronic Kidney Disease

Mar 27, 2023

Patients with chronic kidney disease (CKD) have an increased risk of developing the cardiovascular disease with its sequelae of coronary artery disease, heart failure, and sudden cardiac death. Overall, cardiovascular risk in CKD patients is extremely elevated compared with patients who do not have CKD, leading to significantly enhanced morbidity and mortality once kidney function declines. In fact, the chances of patients with advanced CKD ever reaching the dialysis stage are lower than dying from cardiovascular disease. Ironically, these cardiovascular high-risk patients are often undertreated because of possibly atypical symptoms, concerns about diagnostic work-up involving radiocontrast agents, uncertainty about drugs allowed in advanced CKD, and others. In addition, CKD not only influences the clinical course of cardiovascular disease but also limits the benefit of classic cardiovascular risk-reducing treatments such as lipid-lowering therapy, and, furthermore, the presence of CKD impairs the prognosis of patients after cardiac interventions such as transcatheter aortic valve implantation. Moreover, given the exclusion of patients with advanced CKD from most cardiovascular outcome trials, the database for evidence-based recommendations to treat these patients is limited.

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According to relevant studies,cistanche is a traditional Chinese herb that has been used for centuries to treat various diseases. It has been scientifically proven to possess anti-inflammatory, anti-aging, and antioxidant properties. Studies have shown that cistanche is beneficial for patients suffering from kidney disease. The active ingredients of cistanche are known to reduce inflammation, improve kidney function and restore impaired kidney cells. Thus, integrating cistanche within a kidney disease treatment plan can offer great benefits to patients in managing their condition. Cistanche helps to reduce proteinuria, lowers BUN and creatinine levels, and decreases the risk of further kidney damage. In addition, cistanche also helps reduce cholesterol and triglyceride levels which can be dangerous to patients suffering from kidney disease.

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Cistanche's antioxidant and anti-aging properties help to protect the kidneys from oxidation and damage caused by free radicals. This improves kidney health and reduces the risks of developing complications. Cistanche also helps to boost the immune system, which is essential in fighting off kidney infections and promoting kidney health. By combining traditional Chinese herbal medicine and modern western medicine, those suffering from kidney disease can have a more comprehensive approach to treating the condition and improving their quality of life. Cistanche should be used as part of a treatment plan but is not to be used as an alternative to conventional medical treatments.

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The current issue of Herz addresses various aspects of cardiovascular disease in patients with CKD and focuses on this growing high-risk population. The article by Dr. Schunk and colleagues addresses the pathophysiology and epidemiological aspects of heart and kidney disease, while in his overview Dr. Schlieper discusses cardiovascular workup in advanced CKD. In addition, three articles focus on special aspects of the therapy of patients with advanced CKD including heart failure, coronary artery disease, and cardiac valvular disease, discussing in detail the different treatment options for CKD and offering practical recommendations.

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The group of patients with CKD has been underrecognized in the cardiology field for decades but with its increasing incidence, this population deserves more attention. In addition, given recently developed therapeutic approaches such as treatment with SGLT2 inhibitors or fifinerenone, novel options exist to reduce cardiovascular risk in patients with CKD. Still, the most important aspect in this context is the fact that the current evidence needs to be applied to reduce cardiovascular risk and that CKD patients should be treated based on the results of the most recent cardiovascular outcome trials.
Conflict of interest. N. Marx has received support for clinical trial leadership from Boehringer Ingelheim, Novo Nordisk, served as a consultant to Boehringer Ingelheim, Merck, Novo Nordisk, AstraZeneca, BMS, received grant support from Boehringer Ingelheim, Merck, Novo Nordisk, and served as a speaker for Boehringer Ingelheim, Merck, Novo Nordisk, Lilly, BMS, and Astra Zeneca. N. Marx declines all personal compensation from pharma or device companies. J. Floege served as a consultant to Astellas, AstraZeneca, Bayer, Boehringer Ingelheim, Novartis, and Novo Nordisk.

Ask for more: david.deng@wecistanche.com  WhatApp:86 13632399501

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